Polycef DS Powder for Suspension 100ml

✔️ How does Polycef DS Powder for Suspension work?

Cephradine is a first-generation cephalosporin that inhibits the final transpeptidation step of peptidoglycan synthesis in the bacterial cell wall by binding to one or more penicillin-binding proteins (PBPs). This action arrests cell wall synthesis, leading to bacterial cell death.

✔️ Oral Administration of Polycef DS Powder for Suspension

Can be taken with or without food. Taking meals may reduce gastrointestinal discomfort.

✔️ Side Effects of Polycef DS Powder for Suspension

• Common: Gastrointestinal disturbances, hypersensitivity reactions.
• Rare: Glossitis, heartburn, dizziness, tightness in the chest, nausea, vomiting, diarrhea, abdominal pain, vaginitis, candida overgrowth, skin rashes, joint pains, and edema.
• Very Rare: Blood disorders, serum sickness-like reactions, anaphylaxis, confusion, sleep disturbances, hyperactivity, hepatitis, cholestatic jaundice, reversible interstitial nephritis.

✔️ Quick Suggestions:

• Your child must complete the entire course of antibiotics. Stopping too soon may cause the bacteria to multiply again, become resistant, or cause another infection.
• Give this medicine with food to avoid an upset stomach.
• Encourage your child to drink plenty of water in case diarrhea develops as a side effect.
• Conditions like common cold and flu are caused by viruses. Never use this medicine for such conditions.
• Only give Polycef DS Powder for Suspension to your child for their current infection. Never save medicine for future illnesses.
• Stop this medicine and immediately report to your child’s doctor in case your child develops an itchy rash, facial swelling, or breathing difficulties while taking this medicine.

✔️ Indication of Polycef DS Powder for Suspension

Polycef DS is used to treat infections caused by sensitive Gram-positive and Gram-negative bacteria. These infections include:

• Upper Respiratory Tract Infections: Sinusitis, pharyngitis, tonsillitis, laryngo-tracheo bronchitis, otitis media.
• Lower Respiratory Tract Infections: Bronchitis (acute and chronic), lobar pneumonia, bronchopneumonia.
• Urinary Tract Infections: Cystitis, urethritis, pyelonephritis.
• Skin and Soft Tissue Infections: Abscess, cellulitis, furunculosis, impetigo.

Susceptible Microorganisms:

• Gram-positive: Staphylococci (both penicillin-sensitive and resistant strains), Streptococci, Streptococci pyogenes (beta-hemolytic), Streptococcus pneumonia.
• Gram-negative: Escherichia coli, Klebsiella spp, Proteus mirabilis, Haemophilus influenza, Shigella spp, Salmonella spp (including Salmonella typhi), Neisseria spp.

✔️ Pharmacology

Cephradine is a semisynthetic broad-spectrum bactericidal antibiotic. It works by inhibiting the cross-linking of peptidoglycan in the bacterial cell wall, leading to cell lysis due to osmotic pressure.

✔️ Dosage of Polycef DS Powder for Suspension

For Oral Administration:

Adults:

• Urinary Tract Infections: 500 mg four times daily or 1 g twice daily. Higher doses may be needed for severe or chronic infections.
• Respiratory Tract Infections: 250 to 500 mg four times daily or 500 mg to 1 g twice daily.
• Skin and Soft Tissue Infections: 250 to 500 mg four times daily or 500 mg to 1 g twice daily.

Children:

• General Infections: 25 to 50 mg/kg daily in two or four divided doses.
• Otitis Media: 75 to 100 mg/kg daily in divided doses every 6 to 12 hours.
• Maximum Daily Dose: 4 g.

Elderly:

• Normal adult dosage is appropriate. Monitor patients with impaired renal or hepatic function.

Renal Impairment: Adjust dosage based on creatinine clearance (CrCl).

• CrCl > 20 ml/min: 500 mg every 6 hours.
• CrCl 5-20 ml/min: 250 mg every 6 hours.
• CrCl < 5 ml/min: 250 mg every 50-70 hours.

Chronic, Intermittent Haemodialysis:

• Start of Haemodialysis: 250 mg.
• 6-12 hours after start: 250 mg.
• 36-48 hours after start: 250 mg.
• Next Haemodialysis Session: 250 mg if more than 30 hours have elapsed since the last dose.

✔️ Interaction

• Nephrotoxic Drugs: Increased risk of kidney damage when used with aminoglycosides.
• Diuretics and Probenecid: Enhanced possibility of renal toxicity.

✔️ Contraindications

Known or suspected hypersensitivity to cephalosporins.

✔️ Pregnancy & Lactation

• Pregnancy Category: Not established. Use only if needed.
• Lactation: Excreted in breast milk. Use with caution.

✔️ Precautions & Warnings

• Prolonged use may result in superinfection.
• Use with care in patients hypersensitive to penicillin.
• May cause positive Coombs test results.
• Can cause false positive urine glucose results with certain tests.
• Dosage adjustment is necessary for renal impairment.
• Contains lactose.

✔️ Storage Conditions:

• Use within 7 days at room temperature or within 14 days if refrigerated.
• Keep all medicines out of reach of children.